Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770685 | 0.79 | MAPT (0.46) | MAPTHTR6CXCR4ALDH1A1SMN1; SMN2 | |
| SCHEMBL9770662 | 0.72 | MCL1 (0.49) | MAPTCXCR4ALDH1A1HDAC1HDAC6 | |
| SCHEMBL8618844 | 0.72 | ALDH1A1 (0.40) | MAPTCXCR4ALDH1A1SMN1; SMN2HDAC1 | |
| SCHEMBL3314052 | 0.71 | IGF1R (0.46) | CXCR4ALDH1A1HDAC1HDAC6CYP2D6 | |
| SCHEMBL2597816 | 0.70 | HDAC1 (0.46) | CXCR4ALDH1A1HDAC1HDAC6CYP2D6 | |
| SCHEMBL21060838 | 0.69 | MAPT (0.63) | MAPTHTR6ALDH1A1SMN1; SMN2 | |
| SCHEMBL9934087 | 0.69 | HDAC1 (0.38) | CXCR4HDAC1HDAC6SCN1ASCN5A | |
| SCHEMBL23850650 | 0.68 | HDAC1 (0.41) | CXCR4HDAC1HDAC6CYP2D6 | |
| SCHEMBL12993082 | 0.68 | HDAC1 (0.41) | CXCR4HDAC1HDAC6CYP2D6 | |
| SCHEMBL24804097 | 0.68 | HDAC1 (0.41) | CXCR4HDAC1HDAC6CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5001131-A | Pyridine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1991-03-19 | — | — | US | disclosed |