SCHEMBL8618970

SCHEMBL8618970

CCOC(=O)C1(C(=O)OCC)Oc2ccc(C[C@@H](C)N)cc2O1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.46
SLC6A2 P23975 1/20 0.46
SLC6A4 P31645 1/20 0.46
SLC6A3 Q01959 1/20 0.46
ADRB2 P07550 3/20 0.41
ADRB3 P13945 3/20 0.41
ADRB1 P08588 1/20 0.41
ADRA2A P08913 1/20 0.41
ADRA2B P18089 1/20 0.41
ADRA2C P18825 1/20 0.41
ADRA1D P25100 1/20 0.41
ADRA1A P35348 1/20 0.41
ADRA1B P35368 1/20 0.41
ALOX15 P16050 3/20 0.40
ALOX12 P18054 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
TSHR P16473 1/20 0.39
NFKB1 P19838 1/20 0.39
ALPG P10696 1/20 0.39
PNMT P11086 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8733821 1.00 TAAR1 (0.46) TAAR1SLC6A2SLC6A4SLC6A3ADRB2
Hydrochloric Acid SCHEMBL8620264 0.99 TAAR1 (0.45) TAAR1SLC6A2SLC6A4SLC6A3ADRB2
Hydrochloric Acid SCHEMBL8734036 0.99 TAAR1 (0.45) TAAR1SLC6A2SLC6A4SLC6A3ADRB2
SCHEMBL8432005 0.88 ADRB2 (0.42) ADRB2ADRB3ADRB1ADRA2AADRA2B
SCHEMBL8431744 0.87 ALOX15 (0.40) ADRB2ADRB3ADRB1ADRA2AADRA2B
SCHEMBL8433433 0.87 ADRB2 (0.41) ADRB2ADRB3ADRB1ADRA2AADRA2B
SCHEMBL8859173 0.86 TAAR1 (0.47) TAAR1SLC6A2SLC6A4SLC6A3ADRB2
SCHEMBL8859247 0.86 TAAR1 (0.47) TAAR1SLC6A2SLC6A4SLC6A3ADRB2
SCHEMBL8733806 0.84 ADRB2 (0.54) TAAR1SLC6A2SLC6A4SLC6A3ADRB2
SCHEMBL8733813 0.84 ADRB2 (0.54) TAAR1SLC6A2SLC6A4SLC6A3ADRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5750701-A Heterocyclic ethanolamine derivatives with β-adrenoreceptor agonistic activity SMITHKLINE BEECHAM PLC (GB) 1998-05-12 US disclosed
US-5726165-A HYPOGLYCEMIC AGENTS; DIETETICS; GASTROINTESTINAL DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 1998-03-10 US disclosed
EP-0772585-A1 ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF SMITHKLINE BEECHAM PLC (GB) 1997-05-14 EP disclosed
EP-0750617-A1 NOVEL HETEROCYCLIC ETHANOLAMINE DERIVATIVES WITH BETA-ADRENORECEPTOR AGONISTIC ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1997-01-02 EP disclosed
WO-1996004234-A1 ARYLOXY ANDARYCTHIO PROPANOLAMINE DERIVATIVES USEFUL AS B3-ADRENORECEPTOR AGONISTS AND ANTAGONS OF THE B1 AND B2 ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF SMITHKLINE BEECHAM PLC (GB) 1996-02-15 WO disclosed
WO-1996004233-A1 ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF SMITHKLINE BEECHAM PLC (GB) 1996-02-15 WO disclosed
WO-1995025104-A1 NOVEL HETEROCYCLIC ETHANOLAMINE DERIVATIVES WITH BETA-ADRENORECEPTOR AGONISTIC ACTIVITY SMITHKLINE BEECHAM P.L.C. (GB) 1995-09-21 WO disclosed