SCHEMBL8619008

SCHEMBL8619008

COc1cccc(OC(=O)c2ccccc2)c1C(=O)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 1/20 0.57
KMT2A Q03164 5/20 0.55
SMN1; SMN2 Q16637 4/20 0.55
MEN1 O00255 3/20 0.55
NPC1 O15118 1/20 0.55
RAB9A P51151 1/20 0.55
CA12 O43570 1/20 0.55
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55
CA7 P43166 1/20 0.55
CA9 Q16790 1/20 0.55
CA14 Q9ULX7 1/20 0.55
MAPT P10636 5/20 0.54
ALOX15 P16050 2/20 0.51
HSD17B10 Q99714 2/20 0.51
JAK2 O60674 1/20 0.51
USP2 O75604 1/20 0.51
ESR1 P03372 1/20 0.51
GAA P10253 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8399983 0.91 KMT2A (0.63) SLC6A3KMT2ASMN1; SMN2MEN1NPC1
SCHEMBL9467809 0.89 CA12 (0.67) KMT2ASMN1; SMN2MEN1NPC1RAB9A
SCHEMBL27627508 0.88 CA12 (0.56) KMT2ASMN1; SMN2MEN1NPC1RAB9A
SCHEMBL1671519 0.84 PRSS1 (0.66) SLC6A3KMT2ASMN1; SMN2MEN1CA12
SCHEMBL29749397 0.84 PRSS1 (0.66) SLC6A3KMT2ASMN1; SMN2MEN1CA12
SCHEMBL78197 0.81 ESR1 (0.66) SLC6A3KMT2ASMN1; SMN2MEN1CA12
SCHEMBL28218043 0.81 SLC6A3 (0.57) SLC6A3KMT2ASMN1; SMN2MEN1NPC1
SCHEMBL8527418 0.79 CA12 (0.58) SLC6A3KMT2ASMN1; SMN2MEN1NPC1
SCHEMBL15125784 0.79 CA12 (0.58) KMT2ASMN1; SMN2MEN1NPC1RAB9A
SCHEMBL16236368 0.79 SLC6A3 (0.65) SLC6A3KMT2ASMN1; SMN2MEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0668313-B1 Silylated agents useful for absorbing ultraviolet light GEN ELECTRIC (US) 1998-05-13 EP disclosed
EP-0668313-A1 Silylated agents useful for absorbing ultraviolet light GENERAL ELECTRIC COMPANY (US) 1995-08-23 EP disclosed
US-5391795-A Incorporated with silanetriol hardcoat over a polycarbonate substrate; wear and radiation resistance GENERAL ELECTRIC COMPANY (US) 1995-02-21 US disclosed