Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7756067 | 0.83 | MAPT (0.40) | HRH3HTR7KDM4EMAPTTHRA | |
| SCHEMBL7752192 | 0.83 | HTR7 (0.42) | HRH3HTR7BCHEACHE | |
| SCHEMBL8612335 | 0.83 | HTR7 (0.44) | HRH3HTR7KDM4EMAPTHTR1B | |
| SCHEMBL8615260 | 0.82 | NOS3 (0.39) | HRH3HTR7KDM4EMAPTHTR1B | |
| SCHEMBL8389373 | 0.76 | HTR7 (0.40) | HRH3HTR7KDM4EMAPTTHRB | |
| SCHEMBL15880025 | 0.74 | HRH3 (0.58) | HRH3KDM4EPARP1 | |
| SCHEMBL8619296 | 0.73 | SLC6A4 (0.38) | HRH3KDM4EMAPTTHRBPARP1 | |
| SCHEMBL9098005 | 0.73 | NR4A2 (0.51) | HRH3HTR7KDM4EHTR1B | |
| SCHEMBL14842640 | 0.69 | HTR1B (0.48) | HTR7KDM4EHTR1BDRD2DRD1 | |
| SCHEMBL1572695 | 0.68 | CYP1A2 (0.54) | HRH3HTR7KDM4EHTR1BTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |