Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622920 | 0.82 | NOS1 (0.40) | ALDH1A1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL8624151 | 0.80 | NOS1 (0.39) | ALDH1A1HPGDKMT2ANOS1GAA | |
| Iodophenpropit SCHEMBL13039517 | 0.79 | HRH4 (0.35) | KMT2ACYP1A2CYP3A4MEN1 | |
| SCHEMBL11660028 | 0.78 | HRH3 (0.39) | LMNAHPGDSMN1; SMN2KMT2APKM | |
| Iodophenpropit SCHEMBL30938563 | 0.78 | HRH4 (0.36) | KMT2ACYP1A2CYP3A4MEN1 | |
| SCHEMBL28061468 | 0.78 | CYP2C19 (0.51) | ALDH1A1LMNAHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL8619611 | 0.77 | HRH3 (0.48) | KMT2ACYP1A2CYP3A4NOS1MEN1 | |
| SCHEMBL9867335 | 0.77 | EPHX2 (0.35) | ALDH1A1LMNAHPGDSMN1; SMN2PKM | |
| SCHEMBL9876539 | 0.76 | CYP1A2 (0.38) | ALDH1A1LMNAHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL16840342 | 0.76 | SMN1; SMN2 (0.38) | HPGDSMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573542-B1 | IMIDAZOLE-DERIVATIVES HAVING ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENTS (NL) | 1997-10-15 | — | — | EP | claimed |
| EP-0573542-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H 3?-RECEPTOR. | SEED CAPITAL INVESTMENTS (NL) | 1993-12-15 | — | — | EP | claimed |
| WO-1992015567-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1992-09-17 | — | — | WO | claimed |
| US-5837718-A | ANTIHISTAMINES | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1998-11-17 | — | — | US | disclosed |
| EP-0573542-B1 | IMIDAZOLE-DERIVATIVES HAVING ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENTS (NL) | 1997-10-15 | — | — | EP | disclosed |
| EP-0573542-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H 3?-RECEPTOR. | SEED CAPITAL INVESTMENTS (NL) | 1993-12-15 | — | — | EP | disclosed |
| WO-1992015567-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1992-09-17 | — | — | WO | disclosed |