Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622920 | 0.90 | NOS1 (0.40) | NOS1ALDH1A1ALOX12HPGDMEN1 | |
| Clobenpropit SCHEMBL8312286 | 0.80 | HRH4 (0.40) | MEN1POLBMAPTKMT2AIDO1 | |
| SCHEMBL16840342 | 0.80 | SMN1; SMN2 (0.38) | HPGDMAPTKMT2AL3MBTL1 | |
| SCHEMBL8619610 | 0.80 | ALDH1A1 (0.41) | NOS1ALDH1A1GAAALOX12HPGD | |
| Clobenpropit SCHEMBL15130115 | 0.79 | HRH4 (0.42) | MEN1POLBMAPTKMT2AIDO1 | |
| Clobenprobit SCHEMBL29613706 | 0.79 | HRH4 (0.38) | MEN1POLBMAPTKMT2AIDO1 | |
| SCHEMBL28061468 | 0.76 | CYP2C19 (0.51) | ALDH1A1GAAHPGDGLA | |
| SCHEMBL11660028 | 0.75 | HRH3 (0.39) | HPGDMEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL8617900 | 0.74 | RAB9A (0.43) | ALDH1A1GAAALOX12HPGDL3MBTL1 | |
| SCHEMBL4605920 | 0.73 | GAA (0.53) | ALDH1A1GAAMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5837718-A | ANTIHISTAMINES | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1998-11-17 | — | — | US | disclosed |
| EP-0573542-B1 | IMIDAZOLE-DERIVATIVES HAVING ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENTS (NL) | 1997-10-15 | — | — | EP | disclosed |
| EP-0573542-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H 3?-RECEPTOR. | SEED CAPITAL INVESTMENTS (NL) | 1993-12-15 | — | — | EP | disclosed |
| WO-1992015567-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1992-09-17 | — | — | WO | disclosed |