Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clobenpropit SCHEMBL8312286 | 0.88 | HRH4 (0.40) | HRH4HRH3MAPTKMT2ATP53 | |
| Clobenpropit SCHEMBL15130115 | 0.87 | HRH4 (0.42) | HRH4HRH3MAPTKMT2ATP53 | |
| Clobenprobit SCHEMBL29613706 | 0.85 | HRH4 (0.38) | HRH4HRH3MAPTKMT2AQPCT | |
| SCHEMBL8624151 | 0.80 | NOS1 (0.39) | L3MBTL1MAPTKMT2AHPGD | |
| Iodophenpropit SCHEMBL13039517 | 0.79 | HRH4 (0.35) | HRH4HRH3KMT2ATP53 | |
| Iodophenpropit SCHEMBL30938563 | 0.78 | HRH4 (0.36) | HRH4HRH3KMT2ATP53 | |
| SCHEMBL8619610 | 0.76 | ALDH1A1 (0.41) | SMN1; SMN2MAPTKMT2AHPGD | |
| SCHEMBL9866034 | 0.76 | ALDH1A1 (0.45) | SMN1; SMN2MAPTKMT2AHPGD | |
| SCHEMBL10740166 | 0.74 | HRH1 (0.39) | L3MBTL1HRH3KMT2A | |
| SCHEMBL9867195 | 0.72 | HPGD (0.39) | L3MBTL1MAPTKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688989-B2 | H4 receptor inhibitors for treating tinnitus | SENSORION (FR) | 2017-06-27 | — | — | US | disclosed |
| US-20150176010-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2015-06-25 | — | — | US | disclosed |