Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619879 | 0.84 | EGFR (0.55) | EGFRERBB2ERBB4IRAK4LCK | |
| SCHEMBL8614884 | 0.84 | EGFR (0.47) | EGFRERBB2ERBB4IRAK4LCK | |
| SCHEMBL27939614 | 0.81 | EGFR (0.63) | EGFRKDRLCKSLC2A1RET | |
| SCHEMBL8620302 | 0.81 | ALDH1A1 (0.52) | EGFRABCG2 | |
| SCHEMBL8427361 | 0.78 | CYP3A4 (0.60) | EGFRERBB2ERBB4 | |
| SCHEMBL8308821 | 0.76 | EGFR (0.80) | EGFRERBB2ERBB4ATMRIPK2 | |
| Hydrochloric Acid SCHEMBL8808126 | 0.75 | EGFR (0.58) | EGFRERBB2ERBB4RIPK2EPHB2 | |
| SCHEMBL8616544 | 0.74 | EGFR (0.58) | EGFRERBB2 | |
| SCHEMBL8306919 | 0.74 | KDR (0.65) | EGFRERBB2ERBB4EPHB2KDR | |
| SCHEMBL6187027 | 0.73 | EGFR (0.77) | EGFRERBB2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |