Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309923 | 0.80 | EGFR (0.56) | EGFRFLT3KCNH2HRH3SRC | |
| SCHEMBL8616538 | 0.79 | HRH3 (0.43) | KCNH2HRH3SRCMET | |
| SCHEMBL8619879 | 0.79 | EGFR (0.55) | EGFRERBB2 | |
| SCHEMBL8614884 | 0.76 | EGFR (0.47) | EGFRERBB2 | |
| SCHEMBL8616541 | 0.75 | HRH3 (0.43) | EGFRFLT3EPHX2KCNH2HRH3 | |
| SCHEMBL8620302 | 0.75 | ALDH1A1 (0.52) | EGFR | |
| SCHEMBL8427361 | 0.75 | CYP3A4 (0.60) | EGFRERBB2 | |
| SCHEMBL8620732 | 0.74 | EGFR (0.57) | EGFRERBB2 | |
| SCHEMBL12474212 | 0.71 | EGFR (0.64) | EGFRFLT3AURKBKCNH2HRH3 | |
| SCHEMBL7763005 | 0.71 | EGFR (0.61) | EGFRFLT3AURKBEPHX2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |