SCHEMBL8621119

SCHEMBL8621119

C#CCOc1cc(-c2nn(C)c(SC)c2Cl)c(Cl)cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGK1 P00558 1/20 0.41
KCNH2 Q12809 3/20 0.34
HSP90AB1 P08238 2/20 0.34
LMNA P02545 1/20 0.33
MAOB P27338 2/20 0.31
NR1I2 O75469 1/20 0.31
ADRA2A P08913 1/20 0.31
ADORA3 P0DMS8 1/20 0.31
ADRA2B P18089 1/20 0.31
ADRA2C P18825 1/20 0.31
TACR2 P21452 1/20 0.31
DRD1 P21728 1/20 0.31
SLC6A2 P23975 1/20 0.31
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31
ADORA1 P30542 1/20 0.31
SLC6A4 P31645 1/20 0.31
OPRM1 P35372 1/20 0.31
DRD3 P35462 1/20 0.31
OPRK1 P41145 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8031377 0.80 PGK1 (0.38) PGK1LMNA
SCHEMBL9857082 0.79 PGK1 (0.37) PGK1LMNA
SCHEMBL7694982 0.76 PGK1 (0.40) PGK1KCNH2HSP90AB1LMNAMAOB
SCHEMBL8624020 0.73 POLB (0.34)
SCHEMBL8624333 0.73 POLB (0.31)
SCHEMBL6906104 0.73 PGK1 (0.37) PGK1LMNA
SCHEMBL8624942 0.72 PPOX (0.40) LMNA
SCHEMBL8626251 0.70 KDM1A (0.31)
SCHEMBL8356733 0.70 PGK1 (0.35) PGK1LMNA
SCHEMBL6292288 0.70 PGK1 (0.35) PGK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0443059-B1 3-(Substituted phenyl)pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO LTD (JP) 1998-06-17 EP disclosed
EP-0361114-B1 3-(Substituted phenyl) pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO LTD (JP) 1998-06-03 EP disclosed
EP-0443059-A1 3-(Substituted phenyl)pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO., LTD. (JP) 1991-08-28 EP disclosed
US-5032165-A 3-(substituted phenyl)pyrazole derivatives, salts thereof, and herbicides therefrom NIHON NOHYAKU COMPANY, LTD. (JP) 1991-07-16 US disclosed
EP-0361114-A1 3-(Substituted phenyl) pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO., LTD. (JP) 1990-04-04 EP disclosed