SCHEMBL8621145

SCHEMBL8621145

CCOC(=O)C(C)Sc1cc(-c2nn(C)c(SC)c2Cl)c(Cl)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.38
MAPT P10636 3/20 0.38
TDP1 Q9NUW8 2/20 0.38
LMNA P02545 1/20 0.38
PPOX P50336 2/20 0.35
KDM4E B2RXH2 4/20 0.34
HPGD P15428 3/20 0.34
HSD17B10 Q99714 2/20 0.34
ALOX15 P16050 2/20 0.34
TSHR P16473 3/20 0.33
PRNP P04156 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
GAA P10253 2/20 0.33
POLB P06746 2/20 0.32
MAPK1 P28482 2/20 0.32
RAB9A P51151 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
RXFP1 Q9HBX9 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8621125 0.86 POLB (0.35) LMNAKDM4EPOLB
SCHEMBL9856906 0.83 PPOX (0.35) ALDH1A1MAPTTDP1LMNAPPOX
SCHEMBL8624942 0.82 PPOX (0.40) ALDH1A1MAPTTDP1LMNAPPOX
SCHEMBL8621134 0.80 BAZ2B (0.46) ALDH1A1MAPTTDP1LMNAKDM4E
SCHEMBL9856780 0.76 PPOX (0.34) ALDH1A1MAPTTDP1LMNAPPOX
SCHEMBL8626089 0.74 TDP1 (0.35) ALDH1A1MAPTTDP1LMNAPPOX
SCHEMBL9857029 0.73 ALDH1A1 (0.34) ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL8624020 0.71 POLB (0.34) HPGDHSD17B10TSHRPOLB
SCHEMBL31415315 0.68 SMN1; SMN2 (0.32) ALDH1A1KDM4EHPGDHSD17B10ALOX15
SCHEMBL10447947 0.67 ALDH1A1 (0.35) ALDH1A1MAPTTDP1LMNAPPOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0443059-B1 3-(Substituted phenyl)pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO LTD (JP) 1998-06-17 EP disclosed
EP-0361114-B1 3-(Substituted phenyl) pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO LTD (JP) 1998-06-03 EP disclosed
EP-0443059-A1 3-(Substituted phenyl)pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO., LTD. (JP) 1991-08-28 EP disclosed
US-5032165-A 3-(substituted phenyl)pyrazole derivatives, salts thereof, and herbicides therefrom NIHON NOHYAKU COMPANY, LTD. (JP) 1991-07-16 US disclosed
EP-0361114-A1 3-(Substituted phenyl) pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO., LTD. (JP) 1990-04-04 EP disclosed