Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8617419 | 0.98 | POLB (0.57) | POLBSIGMAR1MAOACHRM2ALDH1A1 | |
| SCHEMBL8621896 | 0.85 | CHRM2 (0.64) | POLBMAOACHRM2ALDH1A1KMT2A | |
| SCHEMBL8614879 | 0.79 | MAOB (0.48) | POLBCHRM2ALDH1A1KMT2AMEN1 | |
| SCHEMBL3182706 | 0.78 | ALDH1A1 (0.62) | POLBALDH1A1KMT2ATDP1MAPT | |
| SCHEMBL8613527 | 0.78 | SIGMAR1 (0.47) | SIGMAR1CHRM2ALDH1A1KMT2AMEN1 | |
| SCHEMBL8613522 | 0.78 | SIGMAR1 (0.47) | SIGMAR1CHRM2ALDH1A1KMT2AMEN1 | |
| SCHEMBL28915906 | 0.78 | ALDH1A1 (0.50) | POLBALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL8642120 | 0.77 | CYP1A2 (0.54) | POLBSIGMAR1MAOACHRM2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8966774 | 0.76 | ALDH1A1 (0.53) | POLBSIGMAR1MAOACHRM2ALDH1A1 | |
| SCHEMBL8619395 | 0.75 | SIGMAR1 (0.47) | SIGMAR1CHRM2ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |