Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | SGPL1 | O95470 | 5/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557014 | 0.84 | MEN1 (0.73) | MEN1KMT2ACYP2D6TACR1KDM4E | |
| SCHEMBL8620404 | 0.83 | CYP2D6 (0.50) | MEN1KMT2ACYP2D6LMNATACR1 | |
| SCHEMBL8626711 | 0.83 | MEN1 (0.50) | MEN1KMT2ALMNATACR1KDM4E | |
| Hydrochloric Acid SCHEMBL8620824 | 0.83 | MEN1 (0.71) | MEN1KMT2ATACR1ALDH1A1BCHE | |
| SCHEMBL6555183 | 0.82 | CYP2D6 (0.49) | MEN1KMT2ACYP2D6LMNATACR1 | |
| SCHEMBL8621287 | 0.82 | SGPL1 (0.52) | MEN1KMT2AKDM4EALDH1A1SGPL1 | |
| SCHEMBL6557248 | 0.74 | MEN1 (0.69) | MEN1KMT2ACYP2D6KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8621357 | 0.73 | MEN1 (0.68) | MEN1KMT2AKDM4EALDH1A1BCHE | |
| SCHEMBL7717818 | 0.73 | MEN1 (0.68) | MEN1KMT2ACYP2D6KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8931151 | 0.72 | MEN1 (0.66) | MEN1KMT2AKDM4EALDH1A1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613458-B1 | ACYCLIC ETHYLENEDIAMINE DERIVATIVES AS SUBSTANCE P RECEPTOR ANTAGONISTS | PFIZER (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5521220-A | Acyclic ethylenediamine derivatives | PFIZER INC. (US) | 1996-05-28 | — | — | US | disclosed |
| WO-1993010073-A1 | ACYCLIC ETHYLENEDIAMINE DERIVATIVES AS SUBSTANCE P RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1993-05-27 | — | — | WO | disclosed |