Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614389 | 0.81 | KDM4E (0.59) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL8615011 | 0.80 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2L3MBTL1NFKB1 | |
| SCHEMBL8966475 | 0.80 | NAMPT (0.56) | NPC1RAB9ASMN1; SMN2L3MBTL1USP2 | |
| SCHEMBL8620030 | 0.80 | RAB9A (0.60) | NPC1RAB9ASMN1; SMN2USP2NAMPT | |
| SCHEMBL8618256 | 0.80 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2L3MBTL1NFKB1 | |
| SCHEMBL17029121 | 0.79 | RAB9A (0.59) | NPC1RAB9ASMN1; SMN2L3MBTL1USP2 | |
| SCHEMBL8617471 | 0.79 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL8620514 | 0.78 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2L3MBTL1NAMPT | |
| SCHEMBL8615169 | 0.78 | KDM4E (0.58) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL8615161 | 0.76 | RAB9A (0.59) | NPC1RAB9ASMN1; SMN2USP2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |