Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620030 | 0.82 | RAB9A (0.60) | SMN1; SMN2NPC1RAB9ALMNANFKB1 | |
| SCHEMBL8966769 | 0.81 | RXFP1 (0.44) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL8621386 | 0.80 | NPC1 (0.59) | SMN1; SMN2NPC1RAB9ALMNANFKB1 | |
| SCHEMBL8614389 | 0.79 | KDM4E (0.59) | SMN1; SMN2NPC1RAB9ALMNANFKB1 | |
| SCHEMBL8615161 | 0.79 | RAB9A (0.59) | SMN1; SMN2NPC1RAB9ALMNANFKB1 | |
| SCHEMBL8617471 | 0.77 | NPC1 (0.68) | SMN1; SMN2NPC1RAB9ALMNANFKB1 | |
| SCHEMBL8615169 | 0.76 | KDM4E (0.58) | SMN1; SMN2NPC1RAB9ALMNANFKB1 | |
| SCHEMBL8618591 | 0.75 | RAB9A (0.56) | SMN1; SMN2NPC1RAB9ALMNANFKB1 | |
| SCHEMBL8616643 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ALMNANFKB1 | |
| SCHEMBL8618103 | 0.74 | NPC1 (0.56) | SMN1; SMN2NPC1RAB9ALMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |