Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 9/20 | 0.61 |
| ▸ | EDNRA | P25101 | 9/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8683767 | 1.00 | EDNRB (0.61) | EDNRBEDNRAALDH1A1KMT2ANPC1 | |
| SCHEMBL8622982 | 0.96 | EDNRB (0.64) | EDNRBEDNRAALDH1A1KMT2A | |
| SCHEMBL8624302 | 0.93 | EDNRB (0.58) | EDNRBEDNRAALDH1A1KMT2ANPC1 | |
| SCHEMBL7810966 | 0.92 | EDNRB (0.75) | EDNRBEDNRA | |
| SCHEMBL8626049 | 0.92 | EDNRA (0.59) | EDNRBEDNRAALDH1A1KMT2A | |
| SCHEMBL8622188 | 0.91 | EDNRB (0.63) | EDNRBEDNRA | |
| SCHEMBL8196385 | 0.81 | EDNRB (0.78) | EDNRBEDNRA | |
| SCHEMBL7942483 | 0.80 | EDNRA (0.79) | EDNRBEDNRA | |
| SCHEMBL7942478 | 0.80 | EDNRA (0.79) | EDNRBEDNRA | |
| SCHEMBL7943708 | 0.80 | EDNRA (0.79) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |