Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.58 |
| ▸ | EDNRA | P25101 | 11/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8683767 | 0.93 | EDNRB (0.61) | EDNRBEDNRAKMT2AALDH1A1HTT | |
| SCHEMBL8622189 | 0.93 | EDNRB (0.61) | EDNRBEDNRAKMT2AALDH1A1HTT | |
| SCHEMBL8622982 | 0.92 | EDNRB (0.64) | EDNRBEDNRAKMT2AALDH1A1 | |
| SCHEMBL7810966 | 0.88 | EDNRB (0.75) | EDNRBEDNRA | |
| SCHEMBL8626049 | 0.88 | EDNRA (0.59) | EDNRBEDNRAKMT2AALDH1A1 | |
| SCHEMBL8622188 | 0.85 | EDNRB (0.63) | EDNRBEDNRA | |
| SCHEMBL7531491 | 0.83 | EDNRA (0.73) | EDNRBEDNRAMGLL | |
| SCHEMBL8196385 | 0.77 | EDNRB (0.78) | EDNRBEDNRA | |
| SCHEMBL7942494 | 0.75 | EDNRA (0.80) | EDNRBEDNRA | |
| SCHEMBL7942483 | 0.75 | EDNRA (0.79) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |