Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 14/20 | 0.59 |
| ▸ | EDNRB | P24530 | 13/20 | 0.59 |
| ▸ | FABP7 | O15540 | 2/20 | 0.46 |
| ▸ | FABP3 | P05413 | 2/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622189 | 0.92 | EDNRB (0.61) | EDNRAEDNRBKMT2AALDH1A1 | |
| SCHEMBL8683767 | 0.92 | EDNRB (0.61) | EDNRAEDNRBKMT2AALDH1A1 | |
| SCHEMBL7810966 | 0.89 | EDNRB (0.75) | EDNRAEDNRB | |
| SCHEMBL8622982 | 0.88 | EDNRB (0.64) | EDNRAEDNRBKMT2AALDH1A1 | |
| SCHEMBL8624302 | 0.88 | EDNRB (0.58) | EDNRAEDNRBKMT2AALDH1A1 | |
| SCHEMBL8622188 | 0.87 | EDNRB (0.63) | EDNRAEDNRBCTNNB1WNT3A | |
| SCHEMBL7943703 | 0.86 | EDNRB (0.78) | EDNRAEDNRBFABP7FABP3FABP5 | |
| SCHEMBL8186694 | 0.80 | EDNRB (0.46) | EDNRAEDNRB | |
| SCHEMBL4586030 | 0.76 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL8176345 | 0.75 | SCD5 (0.45) | EDNRAEDNRBFABP7FABP3FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |