Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 15/20 | 0.64 |
| ▸ | EDNRA | P25101 | 15/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8683767 | 0.96 | EDNRB (0.61) | EDNRBEDNRAALDH1A1KMT2A | |
| SCHEMBL8622189 | 0.96 | EDNRB (0.61) | EDNRBEDNRAALDH1A1KMT2A | |
| SCHEMBL8624302 | 0.92 | EDNRB (0.58) | EDNRBEDNRAALDH1A1KMT2A | |
| SCHEMBL7810966 | 0.91 | EDNRB (0.75) | EDNRBEDNRA | |
| SCHEMBL8622188 | 0.90 | EDNRB (0.63) | EDNRBEDNRA | |
| SCHEMBL8626049 | 0.88 | EDNRA (0.59) | EDNRBEDNRAALDH1A1KMT2A | |
| SCHEMBL7942494 | 0.83 | EDNRA (0.80) | EDNRBEDNRA | |
| SCHEMBL8196385 | 0.82 | EDNRB (0.78) | EDNRBEDNRA | |
| SCHEMBL7942483 | 0.80 | EDNRA (0.79) | EDNRBEDNRA | |
| SCHEMBL7943708 | 0.80 | EDNRA (0.79) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |