Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Triethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL21462763 | 0.97 | MEN1 (0.59) | MEN1KMT2ATSHRLMNAMAPK1 | |
| Diethylene Glycol Monoethyl Ether SCHEMBL6467549 | 0.89 | ALDH1A1 (0.61) | MEN1KMT2ATSHRLMNAMAPK1 | |
| Tromethamine SCHEMBL10457365 | 0.85 | MEN1 (0.44) | MEN1KMT2ATSHRLMNAMAPK1 | |
| SCHEMBL439702 | 0.81 | KDM4E (0.45) | MEN1KMT2ATSHRLMNAMAPK1 | |
| Triethylene Glycol SCHEMBL16685285 | 0.81 | MEN1 (0.58) | MEN1KMT2ATSHRLMNAMAPK1 | |
| Triethylene Glycol SCHEMBL3214314 | 0.80 | MEN1 (0.65) | MEN1KMT2ATSHRLMNAMAPK1 | |
| Hexaethylene Glycol SCHEMBL28607471 | 0.78 | MEN1 (0.85) | MEN1KMT2ATSHRLMNAMAPK1 | |
| Tetraethylene Glycol SCHEMBL28577859 | 0.78 | MEN1 (0.85) | MEN1KMT2ATSHRLMNAMAPK1 | |
| SCHEMBL4092706 | 0.78 | MEN1 (1.00) | MEN1KMT2ATSHRLMNAMAPK1 | |
| SCHEMBL19305255 | 0.78 | MEN1 (1.00) | MEN1KMT2ATSHRLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590365-B1 | A method for producing polyamide with reduced flammability | BASF CORP (US) | 1998-05-27 | — | — | EP | claimed |
| EP-0590365-A1 | A method for producing polyamide with reduced flammability | BASF CORPORATION (US) | 1994-04-06 | — | — | EP | claimed |
| US-5238982-A | Melt mixing polyamide with phosphate ester, melt spinning | BASF CORPORATION (US) | 1993-08-24 | — | — | US | claimed |
| EP-0589284-B1 | Thermoplastic polyamide with reduced flammability | BASF CORP (US) | 1996-11-27 | — | — | EP | disclosed |