Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 known ✓ | O15379 | 2/20 | 0.56 |
| ▸ | HDAC4 known ✓ | P56524 | 2/20 | 0.56 |
| ▸ | HDAC1 known ✓ | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC7 known ✓ | Q8WUI4 | 2/20 | 0.56 |
| ▸ | HDAC2 known ✓ | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC10 known ✓ | Q969S8 | 2/20 | 0.56 |
| ▸ | HDAC11 known ✓ | Q96DB2 | 2/20 | 0.56 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC9 known ✓ | Q9UKV0 | 2/20 | 0.56 |
| ▸ | HDAC5 known ✓ | Q9UQL6 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Lactic Acid SCHEMBL7787988 | 1.00 | MAPT (0.56) | MAPTMEN1KMT2AALDH1A1RXFP1 | |
| Isopropyl Alcohol SCHEMBL11779348 | 0.91 | HSD17B10 (0.58) | MAPTMEN1KMT2AALDH1A1RXFP1 | |
| Diphenylamine SCHEMBL21145224 | 0.85 | MAPT (0.62) | MAPTMEN1KMT2AALDH1A1RXFP1 | |
| Benzene SCHEMBL28162617 | 0.84 | EPHX2 (0.70) | MAPTKMT2AALDH1A1HSD17B10NAPRT | |
| SCHEMBL7634 | 0.84 | EPHX2 (0.70) | MAPTKMT2AALDH1A1HSD17B10NAPRT | |
| Dimethylamine SCHEMBL8779747 | 0.82 | NAPRT (0.62) | MAPTKMT2AHSD17B10NAPRTSMN1; SMN2 | |
| Acetic Acid SCHEMBL6421164 | 0.82 | NAPRT (0.70) | MAPTMEN1KMT2AALDH1A1HSD17B10 | |
| Iodide SCHEMBL5706290 | 0.82 | EPHX2 (0.67) | MAPTKMT2AALDH1A1HSD17B10NAPRT | |
| SCHEMBL11353365 | 0.82 | EPHX2 (0.67) | MAPTKMT2AALDH1A1HSD17B10NAPRT | |
| Bromide SCHEMBL5706299 | 0.82 | EPHX2 (0.67) | MAPTKMT2AALDH1A1HSD17B10NAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1128785-C | Method for producing optically active 1-phenylethylamines | BAYER AG (DE) | 2003-11-26 | — | — | CN | claimed |
| CN-1222140-A | Process for preparing optically active 1-phenyl-ethylamines | BAYER AG (DE) | 1999-07-07 | — | — | CN | claimed |
| JP-10045686-A | — | — | None | — | — | JP | disclosed |
| CN-1128785-C | Method for producing optically active 1-phenylethylamines | BAYER AG (DE) | 2003-11-26 | — | — | CN | disclosed |
| CN-1226228-A | Process for preparing preparing racemic phenethylamines | BAYER AG (DE) | 1999-08-18 | — | — | CN | disclosed |
| CN-1222140-A | Process for preparing optically active 1-phenyl-ethylamines | BAYER AG (DE) | 1999-07-07 | — | — | CN | disclosed |
| JP-H1045686-A | PRODUCTION OF OPTICALLY ACTIVE 1-PHENYL-ETHYLAMINES | BAYER AG | 1998-02-17 | — | — | JP | disclosed |