Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.61 |
| ▸ | CDK9 | P50750 | 1/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7634 | 0.92 | EPHX2 (0.70) | NAPRTHSD17B10EPHX1SMN1; SMN2TSHR | |
| Benzene SCHEMBL28162617 | 0.92 | EPHX2 (0.70) | NAPRTHSD17B10EPHX1SMN1; SMN2TSHR | |
| Dimethylamine SCHEMBL8779747 | 0.90 | NAPRT (0.62) | NAPRTHSD17B10EPHX1SMN1; SMN2TSHR | |
| Water SCHEMBL9215017 | 0.90 | EPHX2 (0.67) | NAPRTHSD17B10EPHX1SMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL9156069 | 0.90 | EPHX2 (0.67) | NAPRTHSD17B10EPHX1SMN1; SMN2TSHR | |
| Water SCHEMBL9215020 | 0.90 | EPHX2 (0.67) | NAPRTHSD17B10EPHX1SMN1; SMN2TSHR | |
| SCHEMBL11353365 | 0.90 | EPHX2 (0.67) | NAPRTHSD17B10EPHX1SMN1; SMN2TSHR | |
| Fluoride SCHEMBL10885265 | 0.90 | EPHX2 (0.67) | NAPRTHSD17B10EPHX1SMN1; SMN2TSHR | |
| Iodide SCHEMBL5706290 | 0.90 | EPHX2 (0.67) | NAPRTHSD17B10EPHX1SMN1; SMN2TSHR | |
| Bromide SCHEMBL5706299 | 0.90 | EPHX2 (0.67) | NAPRTHSD17B10EPHX1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926264-B2 | Phenylcarbamate derivatives as formyl peptide receptor modulators | ALLERGAN, INC. (US) | 2018-03-27 | — | — | US | disclosed |
| EP-3071548-B1 | PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-3071548-A1 | PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2016-09-28 | — | — | EP | disclosed |
| US-20160272581-A1 | PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2016-09-22 | — | — | US | disclosed |
| WO-2015077451-A1 | PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2015-05-28 | — | — | WO | disclosed |
| US-20050045064-A1 | Cellulose acylate film for optical use, and producing method thereof | FUJI PHOTO FILM CO., LTD. (JP) | 2005-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272581-A1 | PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS | FPR2, FPR1, FPR3 | NAPRT 583/4885HSD17B10 3586/4885EPHX1 4078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.