Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | UGCG | Q16739 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622719 | 1.00 | POLB (0.44) | POLBKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8617655 | 0.81 | POLB (0.47) | POLBKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL6551819 | 0.80 | L3MBTL1 (0.52) | KMT2AMEN1UGCGL3MBTL1IGF1R | |
| SCHEMBL8618788 | 0.80 | POLB (0.46) | POLBKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8620885 | 0.71 | ADRB2 (0.50) | ALDH1A1CYP1A2CYP2D6KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL11273763 | 0.71 | L3MBTL1 (0.46) | POLBKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL5754000 | 0.69 | ADRB2 (0.59) | KMT2AMEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL14858345 | 0.68 | UGCG (0.52) | KMT2AMEN1ALDH1A1UGCGDRD2 | |
| SCHEMBL8618033 | 0.68 | L3MBTL1 (0.42) | KMT2AMEN1L3MBTL1DRD2MAOB | |
| SCHEMBL19043634 | 0.67 | HTR1A (0.56) | POLBDRD2DRD1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651735-B1 | PHARMACOLOGICALLY ACTIVE ALPHA-(TERTIARY-AMINOMETHYL)-PHENYLMETHANOL DERIVATIVES | PHARMACIA & UPJOHN AB (SE) | 1998-05-20 | — | — | EP | disclosed |
| US-5527821-A | FOR TREATMENT OF URINARY INCONTINENCE | PHARMACIA AB (SE) | 1996-06-18 | — | — | US | disclosed |
| EP-0651735-A1 | PHARMACOLOGICALLY ACTIVE ALPHA-(TERTIARY-AMINOMETHYL)-PHENYLMETHANOL DERIVATIVES | Pharmacia & Upjohn Aktiebolag (SE) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002442-A1 | PHARMACOLOGICALLY ACTIVE α-[TERTIARY-AMINOMETHYL]-BENZENEMETHANOL DERIVATIVES | PHARMACIA AB (SE) | 1994-02-03 | — | — | WO | disclosed |