Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 10/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8622980 | 1.00 | DGAT1 (0.42) | DGAT1MEN1KMT2AITGB3ITGA2B | |
| SCHEMBL8621442 | 0.99 | DGAT1 (0.43) | DGAT1MEN1KMT2AITGB3ITGA2B | |
| SCHEMBL8621446 | 0.99 | DGAT1 (0.43) | DGAT1MEN1KMT2AITGB3ITGA2B | |
| Bromide SCHEMBL8622380 | 0.87 | DGAT1 (0.34) | DGAT1MEN1KMT2AAOC3SOAT1 | |
| Bromide SCHEMBL8622376 | 0.87 | DGAT1 (0.34) | DGAT1MEN1KMT2AAOC3SOAT1 | |
| SCHEMBL8624527 | 0.80 | MEN1 (0.34) | MEN1KMT2AITGB3ITGA2BAOC3 | |
| Bromide SCHEMBL8627540 | 0.73 | SMN1; SMN2 (0.45) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8621300 | 0.72 | ITGB3 (0.33) | MEN1KMT2AITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL8621305 | 0.72 | ITGB3 (0.33) | MEN1KMT2AITGB3ITGA2B | |
| Bromide SCHEMBL8551655 | 0.70 | LMNA (0.38) | DGAT1ITGB3ITGA2BCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817677-A | ANTITHROMBOSIS AGENTS | DR. KARL THOMAE GMBH (DE) | 1998-10-06 | — | — | US | disclosed |