Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 11/20 | 0.62 |
| ▸ | PPARG | P37231 | 2/20 | 0.54 |
| ▸ | PPARD | Q03181 | 2/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.54 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24723558 | 0.84 | LMNA (0.56) | LMNAL3MBTL1FFAR1PPARGPPARD | |
| SCHEMBL18265475 | 0.84 | PPARD (0.63) | LMNAL3MBTL1FFAR1PPARGPPARD | |
| SCHEMBL24724211 | 0.82 | FFAR1 (0.66) | LMNAL3MBTL1FFAR1PPARGPPARD | |
| SCHEMBL25194799 | 0.82 | LMNA (0.51) | LMNAL3MBTL1FFAR1 | |
| SCHEMBL24723567 | 0.82 | TRPV1 (0.60) | LMNAL3MBTL1FFAR1PPARDFFAR4 | |
| SCHEMBL5092438 | 0.82 | TRPV1 (0.60) | LMNAL3MBTL1FFAR1PPARDFFAR4 | |
| SCHEMBL5092441 | 0.82 | TRPV1 (0.60) | LMNAL3MBTL1FFAR1PPARDFFAR4 | |
| SCHEMBL1205783 | 0.82 | LMNA (0.87) | LMNAL3MBTL1FFAR1PPARGPPARD | |
| SCHEMBL9633693 | 0.81 | FFAR1 (0.55) | LMNAL3MBTL1FFAR1FFAR4 | |
| SCHEMBL12039195 | 0.81 | TRPV1 (0.58) | LMNAL3MBTL1FFAR1PPARDFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |