Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 8/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9127995 | 0.82 | TRPV1 (0.51) | FFAR1KEAP1TRPV1LMNAL3MBTL1 | |
| SCHEMBL9128012 | 0.82 | TRPV1 (0.51) | FFAR1KEAP1TRPV1LMNAL3MBTL1 | |
| SCHEMBL9633738 | 0.81 | ALDH1A1 (0.52) | TRPV1L3MBTL1HSD17B10ALDH1A1 | |
| SCHEMBL8623162 | 0.81 | LMNA (0.64) | FFAR1FFAR4LMNAL3MBTL1 | |
| SCHEMBL24723559 | 0.80 | HSD17B10 (0.44) | FFAR1KEAP1TRPV1HSD17B10ALDH1A1 | |
| SCHEMBL69746 | 0.79 | FFAR1 (0.81) | FFAR1KEAP1FFAR4LMNAL3MBTL1 | |
| SCHEMBL18265475 | 0.78 | PPARD (0.63) | FFAR1FFAR4LMNAL3MBTL1 | |
| Geraniol SCHEMBL28142403 | 0.78 | TRPV1 (0.64) | FFAR1KEAP1TRPV1LMNAHSD17B10 | |
| SCHEMBL24723567 | 0.78 | TRPV1 (0.60) | FFAR1TRPV1FFAR4LMNAL3MBTL1 | |
| SCHEMBL5092438 | 0.78 | TRPV1 (0.60) | FFAR1TRPV1FFAR4LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |