Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 11/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618681 | 0.89 | CCKBR (0.65) | CCKBRSMN1; SMN2CHRM1OPRK1PDE4D | |
| SCHEMBL8637386 | 0.89 | CCKBR (0.65) | CCKBRSMN1; SMN2CHRM1OPRK1PDE4D | |
| SCHEMBL8547144 | 0.87 | CCKBR (0.60) | CCKBRSMN1; SMN2 | |
| SCHEMBL8897135 | 0.84 | CCKBR (0.65) | CCKBRSMN1; SMN2 | |
| SCHEMBL8616738 | 0.84 | CCKBR (0.60) | CCKBRSMN1; SMN2 | |
| SCHEMBL8621834 | 0.82 | CCKBR (0.49) | CCKBRCHRM1 | |
| SCHEMBL8639233 | 0.78 | CCKBR (1.00) | CCKBR | |
| SCHEMBL8616304 | 0.78 | CCKBR (0.72) | CCKBR | |
| SCHEMBL8621915 | 0.73 | CCKBR (0.66) | CCKBR | |
| SCHEMBL8616174 | 0.73 | CCKBR (0.66) | CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558104-B1 | 1,5-Benzodiazepine derivatives and their use in medicine | GLAXO WELLCOME SPA (IT) | 1998-07-29 | — | — | EP | disclosed |
| EP-0623118-B1 | CARBAMATE DERIVATIVES AND THEIR USE IN MEDICINE | GLAXO WELLCOME SPA (IT) | 1998-05-13 | — | — | EP | disclosed |
| US-5637697-A | ANTAGONIST TO GASTRIN AND(OR) CHLOROCYSTOKININ | GLAXO SPA (IT) | 1997-06-10 | — | — | US | disclosed |
| US-5580895-A | GASTROINTESTINAL OR CENTRAL NERVOUS SYSTEM DISORDERS | GLAXO SPA (IT) | 1996-12-03 | — | — | US | disclosed |
| US-5486514-A | GASTRIN, CHOLECYSTOKININ RECEPTOR ANTAGONISTS | GLAXO SPA (IT) | 1996-01-23 | — | — | US | disclosed |
| EP-0558104-A1 | 1,5-Benzodiazepine derivatives and their use in medicine | GLAXO S.p.A. (IT) | 1993-09-01 | — | — | EP | disclosed |