Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 10/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618681 | 0.96 | CCKBR (0.65) | CCKBROPRK1PDE4DCHRM1SMN1; SMN2 | |
| SCHEMBL8623451 | 0.89 | CCKBR (0.64) | CCKBROPRK1PDE4DCHRM1SMN1; SMN2 | |
| SCHEMBL8547144 | 0.87 | CCKBR (0.60) | CCKBRSMN1; SMN2 | |
| SCHEMBL8897135 | 0.87 | CCKBR (0.65) | CCKBRSMN1; SMN2 | |
| SCHEMBL8616738 | 0.82 | CCKBR (0.60) | CCKBRSMN1; SMN2 | |
| SCHEMBL9793664 | 0.81 | OPRK1 (0.60) | CCKBROPRK1PDE4DCHRM1 | |
| SCHEMBL8638925 | 0.79 | CCKBR (1.00) | CCKBR | |
| SCHEMBL8634816 | 0.75 | CCKBR (1.00) | CCKBR | |
| SCHEMBL8615569 | 0.74 | CCKBR (0.73) | CCKBR | |
| SCHEMBL7041976 | 0.73 | CCKBR (0.50) | CCKBRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558104-B1 | 1,5-Benzodiazepine derivatives and their use in medicine | GLAXO WELLCOME SPA (IT) | 1998-07-29 | — | — | EP | disclosed |
| US-5637697-A | ANTAGONIST TO GASTRIN AND(OR) CHLOROCYSTOKININ | GLAXO SPA (IT) | 1997-06-10 | — | — | US | disclosed |
| US-5580895-A | GASTROINTESTINAL OR CENTRAL NERVOUS SYSTEM DISORDERS | GLAXO SPA (IT) | 1996-12-03 | — | — | US | disclosed |
| EP-0558104-A1 | 1,5-Benzodiazepine derivatives and their use in medicine | GLAXO S.p.A. (IT) | 1993-09-01 | — | — | EP | disclosed |
| WO-1993014074-A1 | 1,5-BENZODIAZEPINE DERIVATIVES AND THEIR USE IN MEDICINE | GLAXO SPA (IT) | 1993-07-22 | — | — | WO | disclosed |