Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 4/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14351477 | 0.74 | CA2 (0.53) | CA2CA1LMNACYP2C9SMN1; SMN2 | |
| SCHEMBL14340040 | 0.71 | CA2 (0.61) | CA2CA1LMNACYP2C9SMN1; SMN2 | |
| SCHEMBL8623987 | 0.70 | CA12 (0.40) | CA2CA1LMNACYP2C9SMN1; SMN2 | |
| SCHEMBL19166754 | 0.70 | CA2 (0.64) | CA2CA1LMNACYP2C9SMN1; SMN2 | |
| SCHEMBL8429639 | 0.70 | CA2 (0.60) | CA2CA1LMNACYP2C9SMN1; SMN2 | |
| SCHEMBL15998269 | 0.67 | CA2 (0.50) | CA2CA1LMNACYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL156490 | 0.66 | LMNA (1.00) | CA2CA1LMNACYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL9508286 | 0.65 | LMNA (0.97) | CA2CA1LMNACYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL10778059 | 0.65 | LMNA (0.97) | CA2CA1LMNACYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL10408471 | 0.65 | LMNA (0.97) | CA2CA1LMNACYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | claimed |
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |