Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532653 | 0.86 | FFAR1 (0.41) | HTTL3MBTL1SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL8620891 | 0.81 | MAPT (0.45) | MEN1KMT2AMAPTNPSR1HTT | |
| SCHEMBL8621700 | 0.79 | EDNRA (0.52) | MEN1KMT2ANPSR1MAPK1LMNA | |
| SCHEMBL3584871 | 0.71 | MEN1 (0.46) | MEN1KMT2AMAPTNPSR1HTT | |
| SCHEMBL8626850 | 0.69 | ALDH1A1 (0.47) | MEN1KMT2AMAPTNPSR1HTT | |
| SCHEMBL7534053 | 0.68 | EDNRA (0.73) | — | |
| SCHEMBL18244750 | 0.67 | PREP (0.40) | MEN1KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL6768784 | 0.67 | PREP (0.37) | MEN1KMT2AHTTMAPK1LMNA | |
| SCHEMBL7177838 | 0.67 | PREP (0.37) | MEN1KMT2AHTTMAPK1LMNA | |
| SCHEMBL7531863 | 0.67 | ALDH1A1 (0.63) | MEN1KMT2AMAPTNPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |