Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MPI | P34949 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7804193 | 0.87 | PREP (0.41) | MAPTNPC1TP53HSP90AA1RAB9A | |
| SCHEMBL7813186 | 0.87 | PREP (0.41) | MAPTNPC1TP53HSP90AA1RAB9A | |
| SCHEMBL8620425 | 0.86 | ALDH1A1 (0.54) | ALDH1A1TDP1MAPTKDM4ELMNA | |
| SCHEMBL8627907 | 0.81 | ALDH1A1 (0.44) | ALDH1A1TDP1MAPTKDM4ELMNA | |
| SCHEMBL8623769 | 0.79 | EDNRA (0.49) | ALDH1A1TDP1 | |
| SCHEMBL6958031 | 0.77 | KDM4E (0.53) | ALDH1A1TDP1MAPTKDM4EMEN1 | |
| SCHEMBL8621700 | 0.75 | EDNRA (0.52) | ALDH1A1KDM4ELMNAMEN1MAPK1 | |
| SCHEMBL8624525 | 0.74 | MAPT (0.47) | ALDH1A1TDP1MAPTKDM4ELMNA | |
| SCHEMBL7531863 | 0.74 | ALDH1A1 (0.63) | ALDH1A1TDP1MAPTKDM4ELMNA | |
| SCHEMBL7531421 | 0.72 | NPC1 (0.50) | MAPTNPC1TP53HSP90AA1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |