Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.52 |
| ▸ | EDNRB | P24530 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FABP7 | O15540 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8683478 | 0.87 | EDNRA (0.67) | EDNRAEDNRBALDH1A1TSHRMEN1 | |
| SCHEMBL7534053 | 0.85 | EDNRA (0.73) | EDNRAEDNRB | |
| SCHEMBL8623614 | 0.85 | EDNRA (0.70) | EDNRAEDNRBALDH1A1TSHRMEN1 | |
| SCHEMBL8623838 | 0.83 | EDNRA (0.60) | EDNRAEDNRBALDH1A1TSHRMEN1 | |
| SCHEMBL8624326 | 0.79 | MEN1 (0.39) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL7810966 | 0.77 | EDNRB (0.75) | EDNRAEDNRB | |
| SCHEMBL8626850 | 0.75 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2APOLBKDM4E | |
| SCHEMBL8289267 | 0.74 | MAPK1 (0.49) | EDNRAEDNRBALDH1A1TSHRMEN1 | |
| SCHEMBL8627907 | 0.71 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2APOLBKDM4E | |
| SCHEMBL7589806 | 0.70 | EDNRA (1.00) | EDNRAEDNRBALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |