SCHEMBL8625003

SCHEMBL8625003

C=Cc1ccccc1COc1cccc(C=O)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.64
RAB9A P51151 2/20 0.64
MAOA P21397 8/20 0.60
MAOB P27338 8/20 0.60
TDP1 Q9NUW8 1/20 0.51
CCNB2 O95067 2/20 0.50
CDK1 P06493 2/20 0.50
CDK4 P11802 2/20 0.50
CCNB1 P14635 2/20 0.50
CCND1 P24385 2/20 0.50
CCNB3 Q8WWL7 2/20 0.50
SRC P12931 1/20 0.41
KDM4E B2RXH2 2/20 0.41
ALDH1A1 P00352 1/20 0.41
PKM P14618 1/20 0.41
LCK P06239 1/20 0.40
LMNA P02545 1/20 0.40
TSHR P16473 1/20 0.40
HTT P42858 1/20 0.40
TLR4 O00206 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8625765 0.84 ALDH1A1 (0.51) NPC1RAB9AMAOAMAOBTDP1
SCHEMBL11048902 0.81 NPC1 (0.42) NPC1RAB9AMAOAMAOBTDP1
SCHEMBL11215052 0.80 SMN1; SMN2 (0.46) NPC1RAB9AMAOBKDM4EALDH1A1
SCHEMBL4200604 0.79 NPC1 (0.68) NPC1RAB9AMAOAMAOBTDP1
SCHEMBL8985589 0.79 NPC1 (0.68) NPC1RAB9AMAOAMAOBTDP1
SCHEMBL12517230 0.79 CDK4 (0.75) NPC1RAB9AMAOAMAOBTDP1
SCHEMBL9303235 0.79 NPC1 (0.68) NPC1RAB9AMAOAMAOBTDP1
SCHEMBL9155982 0.79 RAB9A (0.56) NPC1RAB9AMAOAMAOBTDP1
SCHEMBL8625763 0.79 CYP4F2 (0.43) NPC1RAB9AMAOAMAOBCCNB2
SCHEMBL9034897 0.78 NPC1 (1.00) NPC1RAB9AMAOAMAOBTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0597510-B1 Biologically active reagent prepared from aldehyde-containing polymer, test kit, analytical element and methods of use JOHNSON & JOHNSON CLIN DIAG (US) 1998-06-10 EP claimed
US-5401633-A Immunology, label detection EASTMAN KODAK COMPANY (US) 1995-03-28 US claimed
EP-0597510-A1 Biologically active reagent prepared from aldehyde-containing polymer, test kit, analytical element and methods of use Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-05-18 EP claimed
EP-0597510-B1 Biologically active reagent prepared from aldehyde-containing polymer, test kit, analytical element and methods of use JOHNSON & JOHNSON CLIN DIAG (US) 1998-06-10 EP disclosed
US-5401633-A Immunology, label detection EASTMAN KODAK COMPANY (US) 1995-03-28 US disclosed
EP-0597510-A1 Biologically active reagent prepared from aldehyde-containing polymer, test kit, analytical element and methods of use Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-05-18 EP disclosed
US-4478992-A PHOTOGRAPHY EASTMAN KODAK COMPANY (US) 1984-10-23 US disclosed
US-4420630-A BINDERS FOR PHOTOGRAPHY EASTMAN KODAK COMPANY (US) 1983-12-13 US disclosed
US-4335254-A Polymerizable acryloyloxyarylenesulfonamides EASTMAN KODAK COMPANY (US) 1982-06-15 US disclosed
US-4289865-A USEFUL IN RELIEF IMAGES OR AS BINDERS IN PHOTOGRAPHIC MATERIALS EASTMAN KODAK COMPANY (US) 1981-09-15 US disclosed
US-4281207-A CROSSLINKING POLYMERS USEFUL IN RELIEF IMAGES, PHOTORESISTS, AND LITHOGRAPHIC PLATES EASTMAN KODAK COMPANY (US) 1981-07-28 US disclosed
US-4259469-A DESIRABLE SOLUBILITY CHARACTERISTICS FOR USE IN PHOTOLITHOGRAPHY EASTMAN KODAK COMPANY (US) 1981-03-31 US disclosed
US-4225689-A PHOTORESISTS, LITHOGRAPHIC PLATES, RELIF IMAGES EASTMAN KODAK COMPANY (US) 1980-09-30 US disclosed