Tetrahydrofuran

Tetrahydrofuran

SCHEMBL8625099

C1CCOC1.C1CCOC1.c1ccc(C(c2ccccc2)c2cccc3c2Cc2ccccc2-3)cc1

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNMT P11086 1/20 0.40
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
TP53 P04637 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HTR7 P34969 1/20 0.33
HTR2B P41595 1/20 0.33
SRD5A2 P31213 1/20 0.33
PGR P06401 1/20 0.32
KDR P35968 1/20 0.31
ADORA2A P29274 1/20 0.31
ADORA1 P30542 1/20 0.31
CHRM2 P08172 2/20 0.30
CHRM4 P08173 2/20 0.30
CHRM5 P08912 2/20 0.30
CHRM1 P11229 2/20 0.30
CHRM3 P20309 2/20 0.30
DRD2 P14416 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3157927 0.91 PNMT (0.46) PNMTNPC1RAB9ASMN1; SMN2HTR7
SCHEMBL3157875 0.79 PNMT (0.41) PNMTNPC1RAB9ATP53SMN1; SMN2
SCHEMBL3157078 0.79 PNMT (0.41) PNMTNPC1RAB9ATSHRMAPK1
Hydrochloric Acid SCHEMBL6557716 0.77 PNMT (0.35) PNMTNPC1RAB9AHTR7HTR2B
Hydrochloric Acid SCHEMBL6557723 0.77 PNMT (0.35) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL2872051 0.75 PNMT (0.39) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL29067758 0.75 PNMT (0.44) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL5084799 0.74 PGR (0.36) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL10516045 0.74 PNMT (0.49) PNMTNPC1RAB9ASMN1; SMN2HTR7
SCHEMBL3150001 0.73 IDO1 (0.40) PNMTTP53SMN1; SMN2HTR7DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0668295-B1 Spray dried, filled metallocene catalyst composition for use in polyolefin manufacture UNION CARBIDE CHEM PLASTIC (US) 1998-06-03 EP disclosed
US-5674795-A SLURRYING WITH A COCATALYST ACTIVATOR UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1997-10-07 US disclosed
US-5672669-A CONTACTING ETHYLENE WITH A SPRAY DRIED METALLOCENE CATALYST AND A COCATALYST CAPABLE OF ACTIVATING THE CATALYST, AND AN INERT FILLER PARTICLES, HOMO OR COPOLYMERIZATION UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1997-09-30 US disclosed
EP-0593083-B1 Gas phase polymerization reaction utilizing soluble unsupported catalysts UNION CARBIDE CHEM PLASTIC (US) 1996-05-01 EP disclosed
EP-0668295-A1 Spray dried, filled metallocene catalyst composition for use in polyolefin manufacture UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1995-08-23 EP disclosed
US-5317036-A Continuous catalytic vapor phase polymerization of olefins UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1994-05-31 US disclosed
EP-0593083-A1 Gas phase polymerization reaction utilizing soluble unsupported catalysts UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1994-04-20 EP disclosed