Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 2/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29023851 | 0.87 | KDM4E (0.42) | KDM4EPOLBPKMCCR2ALDH1A1 | |
| SCHEMBL10725210 | 0.75 | ALDH1A1 (0.34) | KDM4EPOLBALDH1A1HSP90AA1RXFP1 | |
| SCHEMBL10668244 | 0.75 | KDM4E (0.32) | KDM4EPOLBALDH1A1HSP90AA1RXFP1 | |
| SCHEMBL8096676 | 0.74 | TOP2A (0.47) | KDM4EPOLBALDH1A1HSP90AA1RXFP1 | |
| SCHEMBL10758373 | 0.72 | KDM4E (0.53) | KDM4EPOLBALDH1A1 | |
| SCHEMBL500481 | 0.69 | KDM4E (0.69) | KDM4EPOLBALDH1A1HSP90AA1RXFP1 | |
| SCHEMBL311265 | 0.68 | PIM1 (0.35) | KDM4EPOLBPKM | |
| SCHEMBL3136241 | 0.66 | TOP2A (0.47) | — | |
| SCHEMBL7119198 | 0.65 | MAPT (0.47) | KDM4EALDH1A1STAT3 | |
| SCHEMBL10427427 | 0.64 | STAT3 (0.36) | KDM4EPOLBPKMALDH1A1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684942-B1 | METHOD FOR PREPARING QUINOLINE CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | HOECHST CELANESE CORP (US) | 1998-06-10 | — | — | EP | disclosed |
| EP-0684942-A4 | — | — | 1995-12-27 | — | — | EP | disclosed |
| EP-0684942-A1 | METHOD FOR PREPARING QUINOLINE CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | HOECHST CELANESE CORPORATION (US) | 1995-12-06 | — | — | EP | disclosed |
| US-5430152-A | Heating aminoarylester in presence of chlorosulfonic acid, oleum | HOECHST CELANESE CORPORATION (US) | 1995-07-04 | — | — | US | disclosed |
| WO-1994019312-A1 | METHOD FOR PREPARING QUINOLINE CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | HOECHST CELANESE CORPORATION (US) | 1994-09-01 | — | — | WO | disclosed |