Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | MAT2A | P31153 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760544 | 0.76 | MEN1 (0.53) | MAPTALDH1A1GAARECQLTP53 | |
| SCHEMBL23037281 | 0.75 | TOP2A (0.47) | ALDH1A1KMT2AKDM4ESTAT3 | |
| SCHEMBL7122780 | 0.75 | ALDH1A1 (0.43) | ALDH1A1TP53KMT2AALOX15KDM4E | |
| SCHEMBL1344450 | 0.74 | STAT3 (0.42) | MAPTALDH1A1GAARECQLTP53 | |
| SCHEMBL7123595 | 0.74 | ALDH1A1 (0.41) | MAPTALDH1A1GAAKMT2AKDM4E | |
| SCHEMBL9870208 | 0.74 | STAT3 (0.64) | MAPTALDH1A1TP53KMT2AKDM4E | |
| SCHEMBL22760128 | 0.72 | MEN1 (0.51) | MAPTALDH1A1GAARECQLTP53 | |
| SCHEMBL22760420 | 0.70 | MAPT (0.47) | MAPTALDH1A1GAARECQLTP53 | |
| SCHEMBL29023851 | 0.70 | KDM4E (0.42) | MAPTALDH1A1TP53KDM4EHPGD | |
| SCHEMBL8296756 | 0.70 | ALDH1A1 (0.63) | MAPTALDH1A1GAARECQLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |