SCHEMBL8626495

SCHEMBL8626495

N#Cc1cc(CN2CC[C@H](NS(=O)(=O)c3cccs3)C2=O)ccc1N

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.46
F2 P00734 4/20 0.45
PRSS1 P07477 2/20 0.44
PROC P04070 2/20 0.43
PLAT P00750 1/20 0.43
PLG P00747 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8623632 0.81 F10 (0.56) F10F2PRSS1PROCPLAT
SCHEMBL8040069 0.73 TNKS (0.41)
SCHEMBL8040065 0.70 TNKS (0.43)
SCHEMBL2329937 0.70 F10 (0.51) F10F2PRSS1PROCPLAT
SCHEMBL8622746 0.70 KCNH2 (0.40)
SCHEMBL2325595 0.69 F10 (0.53) F10F2PRSS1PROCPLAT
SCHEMBL8626635 0.68 ALDH1A1 (0.39)
SCHEMBL7425203 0.67 F10 (0.57) F10F2PRSS1PROCPLAT
SCHEMBL2329162 0.66 F10 (0.57) F10F2PROCPLG
SCHEMBL2326538 0.66 F10 (0.63) F10F2PRSS1PROCPLG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5731315-A Substituted sulfonic acid n- (aminoiminomethyl)phenylalkyl!-azaheterocyclamide compounds RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-03-24 US disclosed