SCHEMBL8626732

SCHEMBL8626732

O=S(=O)(O)c1ccccc1C(Nc1nc(Nc2ccccc2)nc(N(CCO)CCO)n1)=C(Nc1nc(Nc2ccccc2)nc(N(CCO)CCO)n1)c1ccccc1S(=O)(=O)O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 7/20 0.42
CA2 P00918 7/20 0.42
CA9 Q16790 7/20 0.42
CA12 O43570 6/20 0.42
RECQL P46063 1/20 0.40
MCL1 Q07820 1/20 0.40
KCNH3 Q9ULD8 6/20 0.40
NPSR1 Q6W5P4 1/20 0.38
CDK2 P24941 2/20 0.38
TTR P02766 1/20 0.38
FABP4 P15090 1/20 0.38
CCNA2 P20248 1/20 0.38
MAPK14 Q16539 1/20 0.38
CCNE2 O96020 1/20 0.37
CCNE1 P24864 1/20 0.37
NR4A1 P22736 1/20 0.37
ALDH1A1 P00352 1/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30880453 0.90 CA1 (0.44) CA1CA2CA9CA12RECQL
SCHEMBL8582932 0.90 CA1 (0.44) CA1CA2CA9CA12RECQL
SCHEMBL30396962 0.89 CA1 (0.55) CA1CA2CA9CA12RECQL
SCHEMBL3657587 0.86 TTR (0.48) CA1CA2CA9CA12RECQL
SCHEMBL30398061 0.86 TTR (0.48) CA1CA2CA9CA12RECQL
SCHEMBL905677 0.82 RHOA (0.47) CA1CA2CA9CA12RECQL
SCHEMBL7098829 0.80 CA1 (0.57) CA1CA2CA9CA12RECQL
SCHEMBL18120691 0.80 CA1 (0.43) CA1CA2CA9CA12RECQL
Calcofluor White SCHEMBL790332 0.79 CA1 (0.40) CA1CA2CA9CA12RECQL
Calcofluor White SCHEMBL790333 0.79 CA1 (0.40) CA1CA2CA9CA12RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999013833-A1 HAIR CARE COMPOSITIONS COMPRISING OPTICAL BRIGHTENERS AND CATIONIC COMPOUNDS THE PROCTER & GAMBLE COMPANY (US) 1999-03-25 WO disclosed