Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8593675 | 0.91 | POLB (0.41) | POLBDRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL8627056 | 0.87 | POLB (0.39) | POLBDRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL8593680 | 0.78 | POLB (0.42) | POLBDRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL8479608 | 0.74 | NPY1R (0.36) | POLBLMNAPSEN1PSEN2APH1B | |
| SCHEMBL8673587 | 0.74 | POLB (0.41) | POLBALDH1A1KMT2AMAPTPSEN1 | |
| SCHEMBL8135190 | 0.74 | POLB (0.50) | POLBDRD2DRD4DRD3LMNA | |
| SCHEMBL8503792 | 0.74 | POLB (0.33) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8666699 | 0.73 | NPY1R (0.33) | POLBLMNAGAA | |
| SCHEMBL8577789 | 0.73 | MTTP (0.45) | — | |
| SCHEMBL8480929 | 0.72 | DRD2 (0.44) | POLBDRD2DRD4DRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0886637-A1 | INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-12-30 | — | — | EP | claimed |
| EP-0886637-A4 | — | — | 1998-12-30 | — | — | EP | claimed |