Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8627056 | 0.91 | POLB (0.39) | POLBDRD2DRD4DRD3PSEN1 | |
| SCHEMBL8480929 | 0.89 | DRD2 (0.44) | POLBDRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL8593675 | 0.86 | POLB (0.41) | POLBDRD2DRD4DRD3PSEN1 | |
| SCHEMBL8712881 | 0.85 | POLB (0.35) | POLBDRD2DRD4DRD3 | |
| SCHEMBL8485778 | 0.85 | NPY1R (0.37) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8713182 | 0.85 | CKS1B (0.38) | POLBDRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL8501237 | 0.85 | MTTP (0.36) | POLBDRD2DRD4DRD3PSEN1 | |
| SCHEMBL8500999 | 0.84 | CTSL (0.37) | POLBDRD2DRD4DRD3PSEN1 | |
| SCHEMBL8665881 | 0.84 | DRD2 (0.37) | POLBDRD2DRD4DRD3NPSR1 | |
| SCHEMBL8502233 | 0.83 | GAA (0.34) | POLBDRD2DRD4DRD3PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0886637-A4 | — | — | 1998-12-30 | — | — | EP | disclosed |
| EP-0886637-A1 | INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-12-30 | — | — | EP | disclosed |
| US-5712279-A | Inhibitors of microsomal triglyceride transfer protein and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-01-27 | — | — | US | disclosed |