Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8593680 | 0.89 | POLB (0.42) | DRD2DRD4DRD3KMT2AMAPT | |
| SCHEMBL8675068 | 0.87 | L3MBTL1 (0.42) | DRD2DRD4DRD3KMT2AMAPT | |
| SCHEMBL8485122 | 0.86 | DRD2 (0.39) | DRD2DRD4DRD3KMT2AMAPT | |
| SCHEMBL8627056 | 0.85 | POLB (0.39) | DRD2DRD4DRD3KMT2AMAPT | |
| SCHEMBL8480412 | 0.85 | DRD2 (0.37) | DRD2DRD4DRD3KMT2AMAPT | |
| SCHEMBL8714745 | 0.84 | CHRM1 (0.41) | DRD2DRD4DRD3KMT2AHPGD | |
| SCHEMBL8502239 | 0.84 | DRD2 (0.39) | DRD2DRD4DRD3KMT2AMAPT | |
| SCHEMBL8503794 | 0.84 | DRD2 (0.38) | DRD2DRD4DRD3KMT2AMAPT | |
| SCHEMBL8669688 | 0.83 | DRD2 (0.39) | DRD2DRD4DRD3NPSR1KDM4E | |
| SCHEMBL8668074 | 0.83 | DRD2 (0.37) | DRD2DRD4DRD3KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883099-A | TREATMENT OF ATHERSCLEROSIS, PANCREATITIS OBESITY OR HYPERGLYCEMIA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-16 | — | — | US | disclosed |