Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 8/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629705 | 0.91 | PTGIR (0.43) | PTGS2F10F2PRSS1PRSS2 | |
| SCHEMBL8630931 | 0.90 | F10 (0.39) | PTGS2F10F2PRSS1PRSS2 | |
| SCHEMBL8631461 | 0.89 | PTGS2 (0.49) | PTGS2PTGS1F10F2PRSS1 | |
| SCHEMBL8632189 | 0.87 | MEN1 (0.50) | F10F2 | |
| SCHEMBL8634432 | 0.85 | PTGS2 (0.44) | PTGS2PTGS1F10F2PRSS1 | |
| SCHEMBL8631834 | 0.85 | PTGS2 (0.46) | PTGS2PTGS1F10F2PRSS1 | |
| SCHEMBL7777697 | 0.84 | PTGS2 (0.46) | PTGS2PTGS1BRAFMAPK3MAPK1 | |
| SCHEMBL8628116 | 0.83 | ALOX5AP (0.41) | PTGS2F10F2PRSS1PRSS2 | |
| SCHEMBL8633277 | 0.82 | PTGS2 (0.50) | PTGS2PTGS1F10F2PRSS1 | |
| SCHEMBL8629992 | 0.82 | PKM (0.48) | PTGS2PTGS1F10F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |