Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533184 | 0.87 | PREP (0.41) | HSP90AA1SMN1; SMN2PREP | |
| SCHEMBL8626850 | 0.81 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4ETDP1NPC1 | |
| SCHEMBL8624525 | 0.72 | MAPT (0.47) | ALDH1A1MAPTKDM4ETDP1NPC1 | |
| SCHEMBL7531863 | 0.72 | ALDH1A1 (0.63) | ALDH1A1MAPTKDM4ETDP1NPC1 | |
| SCHEMBL8621700 | 0.71 | EDNRA (0.52) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL7804193 | 0.69 | PREP (0.41) | MAPTNPC1RAB9ATP53HSP90AA1 | |
| SCHEMBL7813186 | 0.69 | PREP (0.41) | MAPTNPC1RAB9ATP53HSP90AA1 | |
| SCHEMBL7308998 | 0.68 | CA12 (0.53) | ALDH1A1MAPTTDP1NPC1RAB9A | |
| SCHEMBL7363983 | 0.66 | PREP (0.54) | KDM4ENPC1RAB9ATP53KMT2A | |
| SCHEMBL8620425 | 0.65 | ALDH1A1 (0.54) | ALDH1A1MAPTKDM4ETDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |