Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5188575 | 0.88 | KMT2A (0.57) | SMN1; SMN2ALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL8625192 | 0.84 | F10 (0.67) | SMN1; SMN2ALDH1A1KDM4EKEAP1NFE2L2 | |
| SCHEMBL28784798 | 0.81 | LMNA (0.68) | SMN1; SMN2ALDH1A1KDM4EKEAP1NFE2L2 | |
| SCHEMBL6562093 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1KDM4EKEAP1NFE2L2 | |
| SCHEMBL23750114 | 0.79 | LMNA (0.72) | SMN1; SMN2ALDH1A1KEAP1NFE2L2CA12 | |
| SCHEMBL5188860 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL5187402 | 0.79 | ALDH1A1 (0.60) | SMN1; SMN2ALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL23723125 | 0.79 | KMT2A (0.65) | SMN1; SMN2ALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL211196 | 0.78 | HDAC1 (0.71) | SMN1; SMN2ALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL11244161 | 0.77 | PDE4D (0.81) | ALDH1A1KDM4ELMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610320-A | ANTITUMOR AGENTS | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | claimed |
| EP-0472053-B1 | Sulfonamide derivatives | EISAI CO LTD (JP) | 1998-06-17 | — | — | EP | disclosed |
| CN-1036650-C | process for the preparation of sulfonamide derivatives | EISAI CO LTD (JP) | 1997-12-10 | — | — | CN | disclosed |
| US-5610304-A | Pyrimidinyl or pyridinyl sulfonamide substituted compounds | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| US-5610320-A | ANTITUMOR AGENTS | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| CN-1136036-A | Sulfonamide derivatives | EISAI CO LTD (JP) | 1996-11-20 | — | — | CN | disclosed |
| US-5434172-A | Antitumor | EISAI CO., LTD. (JP) | 1995-07-18 | — | — | US | disclosed |
| US-5332751-A | Antitumor | EISAI CO., LTD. (JP) | 1994-07-26 | — | — | US | disclosed |
| US-5292758-A | Sulfonamide derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5250549-A | Antitumor agents | EISAI CO., LTD. (JP) | 1993-10-05 | — | — | US | disclosed |
| CN-1059519-A | Sulfonamide derivatives | EISAI CO LTD (JP) | 1992-03-18 | — | — | CN | disclosed |
| EP-0472053-A2 | Sulfonamide derivatives | Eisai Co., Ltd. (JP) | 1992-02-26 | — | — | EP | disclosed |