Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | ARG1 | P05089 | 2/20 | 0.39 |
| ▸ | PRCP | P42785 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GLI1 | P08151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL16915301 | 0.91 | ARG1 (0.41) | NOS2ARG1PRCPBLMKMT2A | |
| Adipic Acid SCHEMBL16915303 | 0.91 | ARG1 (0.41) | NOS2ARG1PRCPBLMKMT2A | |
| Proline SCHEMBL419844 | 0.91 | NOS2 (0.45) | NOS2NOS3NOS1PRCPBLM | |
| Proline SCHEMBL1125864 | 0.91 | NOS2 (0.45) | NOS2NOS3NOS1PRCPBLM | |
| Proline SCHEMBL302681 | 0.91 | NOS2 (0.45) | NOS2NOS3NOS1PRCPBLM | |
| Proline SCHEMBL302680 | 0.91 | NOS2 (0.45) | NOS2NOS3NOS1PRCPBLM | |
| Proline SCHEMBL3097543 | 0.91 | NOS2 (0.45) | NOS2NOS3NOS1PRCPBLM | |
| D-Proline SCHEMBL18493080 | 0.91 | NOS2 (0.45) | NOS2NOS3NOS1PRCPBLM | |
| Proline SCHEMBL1675389 | 0.91 | NOS2 (0.45) | NOS2NOS3NOS1PRCPBLM | |
| Proline SCHEMBL418934 | 0.91 | NOS2 (0.45) | NOS2NOS3NOS1PRCPBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710252-A | GENETIC ENGINEERING AND POLYPEPTIDES | EASTMAN KODAK COMPANY (US) | 1998-01-20 | — | — | US | disclosed |