Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16692531 | 0.90 | ALDH1A1 (0.40) | PNPCNR1ACP3AOC3MAPT | |
| SCHEMBL21848098 | 0.81 | PNP (0.42) | PNPCNR1ACP3AOC3ALDH1A1 | |
| SCHEMBL12302982 | 0.81 | ALDH1A1 (0.42) | PNPCNR1AOC3MAPTALDH1A1 | |
| SCHEMBL28030148 | 0.81 | ADRB3 (0.43) | PNPACP3LMNAMEN1KMT2A | |
| SCHEMBL11076909 | 0.79 | TSHR (0.36) | CNR1TSHR | |
| SCHEMBL9918240 | 0.79 | AOC3 (0.41) | PNPCNR1AOC3MAPTALDH1A1 | |
| SCHEMBL19592381 | 0.78 | PNP (0.37) | PNPCNR1ACP3AOC3MAPT | |
| SCHEMBL11076888 | 0.77 | CTSB (0.36) | CNR1MEN1KMT2ACYP3A4 | |
| SCHEMBL11080404 | 0.77 | HDAC4 (0.39) | MAPTALDH1A1HPGDLMNAHTT | |
| SCHEMBL11078403 | 0.77 | IDO1 (0.40) | ALDH1A1GAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4436886-A | HEAT-RESISTANT ACETYLENIC POLYMERS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 1984-03-13 | — | — | US | claimed |
| CN-112210549-B | Nitrilase mutant protein and application thereof in catalytic synthesis of (R) -3-substituted-4-cyanobutyric acid compounds | 中国科学院天津工业生物技术研究所 | 2022-06-10 | — | — | CN | disclosed |
| CN-112852789-B | Nitrilase mutant and application thereof | 中国科学院天津工业生物技术研究所 | 2022-04-05 | — | — | CN | disclosed |
| CN-111254134-B | Nitrile hydrolase mutant and application thereof in (S) -mononitrile monoacid synthesis | 中国科学院天津工业生物技术研究所 | 2021-09-07 | — | — | CN | disclosed |
| CN-112852789-A | Nitrilase mutant and application thereof | 中国科学院天津工业生物技术研究所 | 2021-05-28 | — | — | CN | disclosed |
| CN-112210549-A | Nitrilase mutant protein and application thereof in catalytic synthesis of (R) -3-substituted-4-cyanobutyric acid compounds | 中国科学院天津工业生物技术研究所 | 2021-01-12 | — | — | CN | disclosed |
| CN-111254134-A | Nitrile hydrolase mutant and application thereof in (S) -mononitrile monoacid synthesis | 中国科学院天津工业生物技术研究所 | 2020-06-09 | — | — | CN | disclosed |
| US-5726311-A | IMMUNOSUPPRESSANTS | BIOCRYST PHARMACEUTICALS, INC. (US) | 1998-03-10 | — | — | US | disclosed |
| EP-0500653-A4 | INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE | BIOCRYST INC (US) | 1995-08-23 | — | — | EP | disclosed |
| EP-0638080-A4 | 7-DISUBSTITUTED-METHYL-4-OXO-3H -,5H --PYRROLO 3,2-d -]PYRIMIDINE AND PHARMACEUTICAL USES AND COMPOSITIONS CONTAINING THE SAME. | BIOCRYST PHARM INC (US) | 1995-08-23 | — | — | EP | disclosed |
| WO-1993021187-A1 | 7-DISUBSTITUTED-METHYL-4-OXO-3H^_,5H^_-PYRROLO[3,2-d^_]PYRIMIDINE AND PHARMACEUTICAL USES AND COMPOSITIONS CONTAINING THE SAME | BIOCRYST PHARMACEUTICALS, INC. (US) | 1993-10-28 | — | — | WO | disclosed |
| US-5189039-A | 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo[3,2d]pyrimidine and pharmaceutical uses and compositions containing the same | BIOCRYST, INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0500653-A1 | INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE | BIOCRYST PHARMACEUTICALS INC. (US) | 1992-09-02 | — | — | EP | disclosed |
| WO-1991006548-A1 | INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE | BIOCRYST, INC. (US) | 1991-05-16 | — | — | WO | disclosed |
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4417039-A | Cis-enyne aromatic and aromatic heterocyclic polymers | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 1983-11-22 | — | — | US | disclosed |
| US-4380619-A | POLYBENZOTHIAZOLES; N-HETEROCYCLIC POLYMERS; SOLUBILITY; HEAT RESISTANCE; AIRCRAFT; AEROSPACE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 1983-04-19 | — | — | US | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |