Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.45 |
| ▸ | PDE9A | O76083 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | AOC1 | P19801 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628390 | 0.88 | AAK1 (0.63) | AAK1IDO1KDM4CPDE9ALMNA | |
| SCHEMBL6759257 | 0.80 | IDO1 (0.68) | AAK1IDO1LMNAHRH4GRIN1 | |
| SCHEMBL17493802 | 0.79 | AAK1 (0.79) | AAK1IDO1TSHRRECQLCACNA1H | |
| SCHEMBL4111972 | 0.78 | IDO1 (0.70) | AAK1IDO1LMNAHRH4GRIN1 | |
| SCHEMBL25318311 | 0.77 | CYP1A2 (0.56) | KDM4CLMNARECQL | |
| SCHEMBL17494047 | 0.77 | AAK1 (0.81) | AAK1IDO1TSHRRECQLCACNA1H | |
| SCHEMBL9534906 | 0.77 | GRIN2B (0.64) | IDO1GRIN1GRIN2B | |
| SCHEMBL25319558 | 0.75 | CYP1A2 (0.54) | KDM4CRECQL | |
| SCHEMBL8809271 | 0.75 | AAK1 (0.51) | AAK1IDO1LMNACACNA1H | |
| SCHEMBL21034524 | 0.75 | AAK1 (0.51) | AAK1IDO1LMNAGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821675-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033176-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-10-24 | — | — | WO | disclosed |