Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8627840 | 0.93 | KMT2A (0.52) | KMT2AMEN1HSP90AA1PDE3BPDE3A | |
| SCHEMBL8629309 | 0.92 | MEN1 (0.53) | KMT2AMEN1HSP90AA1PPARGSMN1; SMN2 | |
| SCHEMBL8629713 | 0.90 | KMT2A (0.53) | KMT2AMEN1HSP90AA1PPARGPPARD | |
| SCHEMBL8630299 | 0.89 | PLA2G2D (0.50) | KMT2AMEN1HSP90AA1HDAC8 | |
| SCHEMBL6565058 | 0.85 | KMT2A (0.47) | KMT2AMEN1HSP90AA1PDE3BPDE3A | |
| SCHEMBL8629057 | 0.85 | MEN1 (0.52) | KMT2AMEN1HSP90AA1PPARGPPARD | |
| SCHEMBL7744003 | 0.84 | HDAC8 (0.57) | KMT2AMEN1HSP90AA1SMN1; SMN2STAT3 | |
| SCHEMBL8628372 | 0.83 | MEN1 (0.52) | KMT2AMEN1HSP90AA1PPARGPPARD | |
| SCHEMBL8629707 | 0.82 | MCL1 (0.51) | KMT2AMEN1HSP90AA1PDE3BPDE3A | |
| SCHEMBL6564087 | 0.82 | PLA2G2D (0.49) | KMT2AMEN1HSP90AA1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |