Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NAT1 | P18440 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630036 | 0.91 | SMN1; SMN2 (0.44) | MAPTPOLBGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL8629951 | 0.87 | MAPT (0.43) | MAPTPOLBGAAKDM1APTGDR2 | |
| SCHEMBL8632313 | 0.87 | SMN1; SMN2 (0.58) | MAPTPOLBGAASMN1; SMN2KDM1A | |
| SCHEMBL8631200 | 0.86 | PTGDR2 (0.48) | MAPTPOLBGAASMN1; SMN2KDM1A | |
| SCHEMBL8633218 | 0.85 | EDNRB (0.42) | MAPTPOLBGAAKDM1APTGDR2 | |
| SCHEMBL8635404 | 0.85 | MAPT (0.41) | MAPTPOLBGAAKDM1ATP53 | |
| SCHEMBL8631576 | 0.85 | MAPT (0.41) | MAPTPOLBGAAKDM1APTGDR2 | |
| SCHEMBL8630563 | 0.83 | PRMT1 (0.43) | MAPTPOLBGAASMN1; SMN2KDM1A | |
| SCHEMBL8630029 | 0.83 | MEN1 (0.45) | MAPTPOLBGAASMN1; SMN2KDM1A | |
| SCHEMBL8632284 | 0.81 | AR (0.40) | MAPTPOLBGAAKDM1APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |