Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NMT1 | P30419 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MYLK | Q15746 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631588 | 0.91 | GAA (0.47) | SMN1; SMN2GAAALDH1A1NMT1MAPT | |
| SCHEMBL8631200 | 0.90 | PTGDR2 (0.48) | SMN1; SMN2KDM1ATP53PTGDR2GAA | |
| SCHEMBL8632313 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM1ATP53PTGDR2GAA | |
| SCHEMBL8631666 | 0.85 | EDNRB (0.42) | PRMT1KDM1ATP53PTGDR2GAA | |
| SCHEMBL8627773 | 0.85 | PRMT1 (0.42) | PRMT1KDM1ATP53PTGDR2GAA | |
| SCHEMBL8628554 | 0.85 | PRMT1 (0.41) | PRMT1SMN1; SMN2KDM1ATP53PTGDR2 | |
| SCHEMBL8628706 | 0.83 | MAPT (0.44) | SMN1; SMN2KDM1ATP53PTGDR2GAA | |
| SCHEMBL8630029 | 0.83 | MEN1 (0.45) | SMN1; SMN2KDM1ATP53PTGDR2GAA | |
| SCHEMBL8630962 | 0.83 | PTGS2 (0.44) | PRMT1KDM1ATP53PTGDR2GAA | |
| SCHEMBL8631648 | 0.83 | AR (0.41) | PRMT1KDM1ATP53PTGDR2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |